TitleEvolution of lactase persistence: an example of human niche construction.
Publication TypeJournal Article
Year of Publication2011
AuthorsGerbault, P, Liebert, A, Itan, Y, Powell, A, Currat, M, Burger, J, Swallow, DM, Thomas, MG
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume366
Pagination863–877
ISSN0962-8436
Keywordsdairying, domestic animals, lactase persistence, neolithic, niche construction
Abstract

Niche construction is the process by which organisms construct important components of their local environment in ways that introduce novel selection pressures. Lactase persistence is one of the clearest examples of niche construction in humans. Lactase is the enzyme responsible for the digestion of the milk sugar lactose and its production decreases after the weaning phase in most mammals, including most humans. Some humans, however, continue to produce lactase throughout adulthood, a trait known as lactase persistence. In European populations, a single mutation (-13910*T) explains the distribution of the phenotype, whereas several mutations are associated with it in Africa and the Middle East. Current estimates for the age of lactase persistence-associated alleles bracket those for the origins of animal domestication and the culturally transmitted practice of dairying. We report new data on the distribution of -13910*T and summarize genetic studies on the diversity of lactase persistence worldwide. We review relevant archaeological data and describe three simulation studies that have shed light on the evolution of this trait in Europe. These studies illustrate how genetic and archaeological information can be integrated to bring new insights to the origins and spread of lactase persistence. Finally, we discuss possible improvements to these models.

DOI10.1098/rstb.2010.0268