TitleHepatoprotective and antioxidant effects of single clove garlic against CCl4-induced hepatic damage in rabbits
Publication TypeJournal Article
Year of Publication2017
AuthorsNaji, KMohammed, Al-Shaibani, EShukri, Alhadi, FA, Al-Soudi, S'aAbdulrzaq, D'souza, MR
JournalBMC Complementary and Alternative Medicine
KeywordsAllium sativum, Antioxidant, Biochemical parameters, Carbon tetrachloride, Hepatotoxicity, Oxidative toxicity, Single clove garlic

BACKGROUND The increase in demand and consumption of single clove garlic or 'Solo garlic' (Allium sativum) has resulted in an increase in research on its therapeutic properties. The present study aims to evaluate the antioxidant activities, oxidant-scavenging efficiency and preventive effects of SCG (single clove garlic) and MCG (multi clove garlic) on CCl4-induced acute hepatotoxicity in male rabbits. METHODS For this purpose, rabbits were orally administered with 3 ml of CCl4 /kg of body weight, followed by 0.8 g of MCG or SCG/kg twice a week for three successive weeks. Oxidative hepatotoxicity was then assessed. RESULTS SCG extracts exhibited higher antioxidant capacity than the MCG extract. Scavenging ability of SCG showed significant (p